Publications

All data generated by the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative are available to the research community through the NCI Data Coordinating Center (DCC) and the TARGET Data Portal. Included here is a list of publications from TARGET Researchers to date:

Zhang J., Mullighan C.G., Harvey R.C., Wu G., Chen X., Edmonson M., Buetow K.H., Carroll W.L., Chen I.M., Devidas M., Gerhard D.S. et al. (2011) Key pathways are frequently mutated in high risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood 2011 Jun 16. (Epub ahead of print). View PubMed abstract.

Yang, J.J., Cheng, C., Devidas, M., Cao, X., Fan, Y., Campana, D., Yang, W., Neale, G., Cox, N.J., Scheet, P., et al. (2011) Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia. Nat Genet. 2011 Feb 6. (Epub ahead of print). View PubMed abstract.

Harvey, R.C., Mullighan, C.G., Wang, X., Dobbin, K.K., Davidson, G.S., Bedrick, E.J., Chen, I.M., Atlas, S.R., Kang, H., Ar, K., et al. (2010) Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood 116(23):4874-4884. View PubMed abstract.

Harvey, R.C., Mullighan, C.G., Chen, I.M., Wharton, W., Mikhail, F.M., Carroll, A.J., Kang, H., Liu, W., Dobbin, K.K., Smith, M.A., et al. (2010) Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. Blood 115(26): 5312-5321. View PubMed abstract.

Kang, H., Chen, I.M., Wilson, C.S., Bedrick, E.J., Harvey, R.C., Atlas, S.R., Devidas, M., Mullighan, C.G., Wang, X., Murphy, M., et al. (2010) Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia. Blood 115(7): 1394-1405. View PubMed abstract.

Mullighan, C.G., Collins-Underwood, J.R., Phillips, L.A., Loudin, M.G., Liu, W., Zhang, J., Ma, J., Coustan-Smith, E., Harvey, R.C., Willman, C.L., et al. (2010) Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia. Nat Genet. 41(11):1243-1246. View PubMed abstract.

Mullighan, C.G., Zhang, J., Harvey, R.C., Collins-Underwood, J.R., Schulman, B.A., Phillips, L.A., Tasian, S.K., Loh, M.L., Su, X., Liu, W., et al. (2009) JAK mutations in high-risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 106(23):9414-9418. View PubMed abstract.

Mullighan, C.G., Su, X., Zhang, J., Radtke, I., Phillips, L.A., Miller, C.B., Ma, J., Liu, W., Cheng, C., Schulman, B.A., et al. (2009) Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 360(5):470-480. View PubMed abstract.