NATIONAL CANCER INSTITUTE NATIONAL CANCER INSTITUTE
Therapeutically Applicable Research to Generate Effective Treatments
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Promoting Discoveries

Leading to Cures

What is TARGET? The Therapeutically Applicable Research to Generate Effective Treatments (TARGET) Initiative seeks to harness the power of modern genomics technologies to rapidly identify valid therapeutic targets in childhood cancers so that new, more effective treatments can be developed and ultimately bring new hope to children and their families who face the devastating burden of these diseases.

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TARGET Podcast: NCI's Malcolm Smith, M.D., Ph.D., explains the impact of genomics research on the treatment of pediatric cancers.

ARRA Supports TARGET Expansion; Five Childhood Tumors Now Being Analyzed

Five investigators have received Administrative Supplements using American Reinvestment and Recovery Act (ARRA) funding. This funding will add acute myelogenous leukemia, osteosarcoma and Wilms tumor to the TARGET portfolio and expand ongoing ALL and neuroblastoma research. Read more about the TARGET expansion.

The TARGET Initiative pursues three primary areas of research:

The TARGET Initiative is currently focused on identifying therapeutic targets in five childhood cancers:

  • Acute Myelogenous Leukemoa
  • High-risk Acute Lymphoblastic Leukemia (ALL)
  • Neuroblastoma
  • Osteosarcoma
  • Wilms Tumor

These cancers were the chosen for study because of their prevalence among children, the inadequacy of current treatment options and the availability of human tissue collections that met TARGET's strict scientific, technical, and ethical requirements. Learn more about the cancers selected for study by TARGET.

In the TARGET Initiative, the National Cancer Institute (NCI) actively collaborates with several world-class institutions to identify valid therapeutic targets in childhood cancers. Learn more